Anti- Candida Activity of a New Platinum Derivative-Reference-Cited by-同舟云学术

Anti- Candida Activity of a New Platinum Derivative

Published:2000-10 Issue:10 Volume:44 Page:2853-2854
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Watanabe T.¹,Takano M.¹,Ogasawara A.¹,Mikami T.¹,Kobayashi T.²,Watabe M.²,Matsumoto T.¹

Affiliation:

1. Department of Microbiology, Tohoku Pharmaceutical University, Sendai 981-8558,1 and

2. General Education Department, Kogakuin University, Hachioji, Tokyo 192-0015,2 Japan

Abstract

ABSTRACT A new platinum derivative of the form H[Pt(IV)(Hdigly)Cl 2 (OH) 2 ] (Hdiglyglycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV)(Hdigly)Cl 2 (OH) 2 ] on mammalian cells was 10-fold lower than that of cis -diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.10.2853-2854.2000

Reference15 articles.

1. A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay.;Ahmed S. A.;J. Immunol. Methods,1994

2. Putative virulence factors of Candida albicans.;Cultler J. E.;Annu. Rev. Microbiol.,1991

3. Total sodium, potassium and chloride in adult man.;Forbes G. B.;J. Clin. Investig.,1956

4. In vitro cytotoxicities and in vivo distribution of transferrin-platinum(II) complex.;Hoshino T.;J. Pharm. Sci.,1995

5. Platinum(II) complexes with diglycine: X-ray crystal structure, 15N NMR spectra, and growth-inhibitory activity against mouse Meth A solid tumor in vivo.;Nagao N.;Inorg. Chem.,1997

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Platinum(IV) compounds as potential drugs: a quantitative structure-activity relationship study;BioImpacts;2023-01-07

2. Platinum(II) Complexes [Ph3PCH2OH]2[PtCl4] and trans-PtCl2(PPh3)2]⋅CHCl3: Synthesis, Crystal Structures, and Thermal Stability;Russian Journal of Coordination Chemistry;2022-06

3. Hybrid Molecules Containing a 7-Chloro-4-aminoquinoline Nucleus and a Substituted 2-Pyrazoline with Antiproliferative and Antifungal Activity;Molecules;2016-07-27

4. Unnatural amino acid-mediated synthesis of silver nanoparticles and their antifungal activity against Candida species;Journal of Nanoparticle Research;2014-08

5. Antifungal activity of nontraditional antifungal agents;Current Fungal Infection Reports;2009-05-10