PMS-601, a New Platelet-Activating Factor Receptor Antagonist That Inhibits Human Immunodeficiency Virus Replication and Potentiates Zidovudine Activity in Macrophages-Reference-Cited by-同舟云学术

PMS-601, a New Platelet-Activating Factor Receptor Antagonist That Inhibits Human Immunodeficiency Virus Replication and Potentiates Zidovudine Activity in Macrophages

Published:2000-11 Issue:11 Volume:44 Page:3150-3154
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Martin M.¹,Serradji N.²,Dereuddre-Bosquet N.¹³,Le Pavec G.¹,Fichet G.¹,Lamouri A.²,Heymans F.²,Godfroid J. J.²,Clayette P.¹³,Dormont D.¹

Affiliation:

1. CEA, Service de Neurovirologie, DSV/DRM, CRSSA, EPHE, Institut Paris-Sud sur les Cytokines, Fontenay aux Roses,1

2. Université Denis Diderot-Paris VII, Laboratoire de Pharmacochimie Moléculaire, Paris,2 and

3. SPI-BIO, Massy,3France

Abstract

ABSTRACT We assessed the anti-human immunodeficiency virus (anti-HIV) activity in vitro of new platelet-activating factor (PAF) receptor antagonists, as PAF and viral replication are thought to be involved in HIV neuropathogenesis. We found that PMS-601 inhibited proinflammatory cytokine synthesis and HIV replication in macrophages and potentiated the antiretroviral activity of zidovudine. These results suggest that PMS-601 is of potential value as an adjuvant treatment for HIV infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.11.3150-3154.2000

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