Methionine Interference in Rapamycin Production Involves Repression of Demethylrapamycin Methyltransferase and S -Adenosylmethionine Synthetase-Reference-Cited by-同舟云学术

Methionine Interference in Rapamycin Production Involves Repression of Demethylrapamycin Methyltransferase and S -Adenosylmethionine Synthetase

Published:2000-10 Issue:10 Volume:44 Page:2908-2910
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kim Wan-Seop¹,Wang Yi¹,Fang Aiqi¹,Demain Arnold L.¹

Affiliation:

1. Fermentation Microbiology Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Abstract

ABSTRACT In a chemically defined medium, l -methionine decreased production of rapamycin and increased that of demethylrapamycin. Growth with l -methionine yielded cells with a lower ability to convert demethylrapamycin to rapamycin and decreased the level of S -adenosylmethionine synthetase and S -adenosylmethionine. Thus, methionine represses at least one methyltransferase of rapamycin biosynthesis and S -adenosylmethionine synthetase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.10.2908-2910.2000

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