In Vitro Susceptibilities of Capnocytophaga Isolates to β-Lactam Antibiotics and β-Lactamase Inhibitors

Author:

Jolivet-Gougeon Anne1,Buffet Anne1,Dupuy Cécile1,Sixou Jean-Louis2,Bonnaure-Mallet Martine2,David Sandrine1,Cormier Michel1

Affiliation:

1. Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254,1 and

2. Equipe de Biologie Buccale, UPRES-EA 1256, UFR Odontologie,2 Université de Rennes I, 35000 Rennes, France

Abstract

ABSTRACT The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga , even beta-lactamase producers, indicates that these beta-lactamase inhibitors could be used for empirical treatment of neutropenic patients with oral sources of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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