Antimalarial Activities of Polyhydroxyphenyl and Hydroxamic Acid Derivatives-Reference-Cited by-同舟云学术

Antimalarial Activities of Polyhydroxyphenyl and Hydroxamic Acid Derivatives

Published:1998-09 Issue:9 Volume:42 Page:2456-2458
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Holland Kevin P.¹,Elford Howard L.²,Bracchi Valerie³,Annis Charles G.¹,Schuster Sheldon M.¹,Chakrabarti Debopam¹³

Affiliation:

1. Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 326111;

2. Molecules for Health, Inc., Virginia Biotechnology Center, Richmond, Virginia 232192; and

3. Department of Molecular Biology and Microbiology and Center for Diagnostics and Drug Development, University of Central Florida, Orlando, Florida 328163

Abstract

ABSTRACT Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum . Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.9.2456

Reference19 articles.

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5. Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas.;Elford H. L.;J. Biol. Chem.,1970

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