Susceptibilities of Candida Species Isolated from the Lower Gastrointestinal Tracts of High-Risk Patients to the New Semisynthetic Echinocandin LY303366 and Other Antifungal Agents

Author:

Zhanel George G.1234,Karlowsky James A.123,Zelenitsky Sheryl A.2,Turik Michael A.5,Hoban Daryl J.13

Affiliation:

1. Department of Medical Microbiology1 and

2. Faculty of Pharmacy,2 University of Manitoba, and

3. Departments of Clinical Microbiology3and

4. Medicine,4 Health Sciences Centre, Winnipeg, Manitoba, Canada, and

5. Lilly Research Laboratories, Indianapolis, Indiana5

Abstract

ABSTRACT Fifty-two percent of stool specimens collected from 1,200 high-risk patients were colonized with yeasts, primarily Candida albicans (53.6%) and Candida glabrata (35.7%). Susceptibilities to all antifungal agents tested, including LY303366, were similar to those reported previously for Candida species isolated from blood.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Edwards J. E. Candida species Principles and practice of infectious diseases 4th ed. Mandell G. L. Bennett J. E. Dolin R. 1995 2289 2305 Churchill Livingstone Inc. New York N.Y

2. Antifungal dynamics of LY303366, an investigational echinocandin B analog, against Candida ssp.;Ernst M. E.;Diagn. Microbiol. Infect. Dis.,1996

3. Candidemia in a Canadian tertiary care hospital from 1976 to 1996.;Karlowsky J. A.;Diagn. Microbiol. Infect. Dis.,1997

4. Mechanisms of association of Candida albicans with intestinal mucosa.;Kennedy M. J.;J. Med. Microbiol.,1987

5. Merz W. G. Roberts G. D. Detection and recovery of fungi from clinical specimens Manual of clinical microbiology. Murray P. R. Baron E. J. Pfaller M. A. Tenover F. C. Yolken R. H. 1995 709 722 American Society for Microbiology Washington D.C

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