A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia-Reference-Cited by-同舟云学术

A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia

Published:1998-09 Issue:9 Volume:42 Page:2443-2445
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Marttila Harri J.¹,Soini Hanna¹,Eerola Erkki²,Vyshnevskaya Elena³,Vyshnevskiy Boris I.³,Otten Tatjana F.³,Vasilyef Alexandr V.³,Viljanen Matti K.¹

Affiliation:

1. Mycobacterial Reference Laboratory, National Public Health Institute,1 and

2. Department of Medical Microbiology University of Turku,2 Kiinamyllynkatu 13, 20520 Turku, Finland, and

3. Research Institution of Phthisiopulmonology, St. Petersburg, Russia3

Abstract

ABSTRACT Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG , and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS 6110 fingerprints.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.9.2443

Reference21 articles.

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