Affiliation:
1. Department of Microbiology and Immunology, Shimane Medical University, Izumo 693, Japan
Abstract
Various types of mouse peritoneal macrophages were studied for H
2
O
2
release in the presence of wheat germ lectin or phorbol myristate acetate. Macrophages elicited 3 days before harvest by a single injection of thioglycolate, zymosan A, or a streptococcal preparation (OK-432) were highly responsive to wheat germ lectin, resulting in a marked increase in H
2
O
2
release. However, immunologically activated macrophages induced by double injections of live and heat-killed BCG at 15 and 3 days before harvest or by double injections of zymosan A or OK-432 at 20 and 3 days before harvest did not show any significant response to wheat germ lectin. On the other hand, all macrophages tested responded well to phorbol myristate acetate by augmentation of H
2
O
2
release. Concanavalin A inhibited wheat germ lectin- and phorbol myristate acetate-triggered H
2
O
2
release from all types of macrophages, but inhibition was much more marked in the case of wheat germ lectin-stimulated H
2
O
2
release. Succinylated concanavalin A (divalent concanavalin A) showed only slight suppressive action against macrophage H
2
O
2
release, and prostaglandin E
1
and dibutyryl cyclic adenosine 3′, 5′-monophosphate caused depression of H
2
O
2
release from OK-432-induced macrophages.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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