Indomethacin promotes differentiation of Trypanosoma brucei-Reference-Cited by-同舟云学术

Indomethacin promotes differentiation of Trypanosoma brucei

Published:1984-01 Issue:1 Volume:43 Page:445-448
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jack R M,Black S J,Reed S L,Davis C E

Abstract

The treatment of mice with indomethacin lowered Trypanosoma brucei parasitemia 1 to 2 log10 because it quickly promoted the differentiation of rapidly dividing long, slender trypanosomes into short, stumpy forms that do not divide in the mammal but do develop a functional mitochondrion and the ability to infect the tsetse. Since natural resistance correlates with the rate of differentiation, this observation may provide important information about factors that control the severity of trypanosomiasis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.43.1.445-448.1984

Reference22 articles.

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