Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum-Reference-Cited by-同舟云学术

Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum

Published:2008-02 Issue:2 Volume:52 Page:774-777
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barthel Diana¹,Schlitzer Martin²,Pradel Gabriele¹

Affiliation:

1. Research Center for Infectious Diseases, University of Würzburg, 97070 Würzburg, Germany

2. Department of Pharmaceutical Chemistry, Philipps-University Marburg, D-35032 Marburg, Germany

Abstract

ABSTRACT Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum . Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00892-07

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