A Standard Numbering Scheme for Class C β-Lactamases-Reference-Cited by-同舟云学术

A Standard Numbering Scheme for Class C β-Lactamases

Published:2020-02-21 Issue:3 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mack Andrew R.¹²^ORCID,Barnes Melissa D.³²,Taracila Magdalena A.³²,Hujer Andrea M.³²,Hujer Kristine M.³²,Cabot Gabriel⁴⁵^ORCID,Feldgarden Michael⁶,Haft Daniel H.⁶,Klimke William⁶,van den Akker Focco⁷,Vila Alejandro J.⁸⁹¹⁰¹¹,Smania Andrea¹²¹³,Haider Shozeb¹⁴,Papp-Wallace Krisztina M.³⁷¹⁵²^ORCID,Bradford Patricia A.¹⁶^ORCID,Rossolini Gian Maria¹⁷¹⁸,Docquier Jean-Denis¹⁹,Frère Jean-Marie²⁰,Galleni Moreno²⁰,Hanson Nancy D.²¹,Oliver Antonio⁴⁵^ORCID,Plésiat Patrick²²²³²⁴^ORCID,Poirel Laurent²⁵²⁶,Nordmann Patrice²⁵²⁶,Palzkill Timothy G.²⁷²⁸^ORCID,Jacoby George A.²⁹,Bush Karen³⁰^ORCID,Bonomo Robert A.¹³³¹⁷¹⁵

Affiliation:

1. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

2. Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

3. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

4. Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain

5. Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain

6. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

7. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

8. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

9. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina

10. Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina

11. Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

12. Centro de Investigaciones en Química Biológica de Córodoba (CIQUIBIC), CONICET, Universidad Nacional de Córdoba, Córdoba, Argentina

13. Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina

14. UCL School of Pharmacy, University College London, London, United Kingdom

15. Department of Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA

16. Antimicrobial Development Specialists, LLC, Nyack, New York, USA

17. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

18. Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy

19. Department of Medical Biotechnology, University of Siena, Siena, Italy

20. Centre for Protein Engineering (CIP), University of Liège, Liège, Belgium

21. Department of Microbiology and Immunology, Creighton School of Medicine, Omaha, Nebraska, USA

22. Laboratoire de Bactériologie, Centre Hospitalier Régional Universitaire, Besançon, France

23. UMR6249 CNRS Chrono-Environnement, Université de Bourgogne Franche-Comté, Besançon, France

24. Centre National de Référence de la Résistance aux Antibiotiques, Besançon, France

25. Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland

26. Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland

27. Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA

28. Verna Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA

29. Lahey Hospital and Medical Center, Burlington, Massachusetts, USA

30. Department of Biology, Indiana University Bloomington, Bloomington, Indiana, USA

31. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser 64 , Lys 67 , Tyr 150 , and Lys 315 ), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Biomedical Laboratory Research and Development, VA Office of Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01841-19

Reference17 articles.

1. The ABCD’s of β-lactamase nomenclature

2. AmpC β-Lactamases