High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis-Reference-Cited by-同舟云学术

High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis

Published:2019-02 Issue:2 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Grégoire Matthieu¹²^ORCID,Gaborit Benjamin³⁴,Deschanvres Colin³,Lecomte Raphaël³,Deslandes Guillaume¹,Dailly Éric¹⁵,Ambrosi Xavier⁶,Bellouard Ronan¹⁵,Asseray Nathalie³,Lakhal Karim⁶,Boutoille David³⁴

Affiliation:

1. Clinical Pharmacology Department, CHU Nantes, Nantes, France

2. UMR Inserm 1235 The Enteric Nervous System in Gut and Brain Disorders, University of Nantes, Nantes, France

3. Infectious Diseases Department, CHU Nantes and CIC 1413, Inserm, Nantes, France

4. EA 3826 Thérapeutiques Cliniques et Expérimentales des Infections, University of Nantes, Nantes, France

5. EE1701 Microbiotas, Hosts, Antibiotics and Bacterial Resistances, University of Nantes, Nantes, France

6. Réanimation Chirurgicale Polyvalente, Service d’Anesthésie-Réanimation, Hôpital Laënnec, CHU Nantes, Nantes, France

Abstract

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01844-18

Reference12 articles.

1. Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study

2. Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center

3. Prevention of external ventricular drain ? related ventriculitis

4. Nosocomial ventriculitis and meningitis in neurocritical care patients

5. Influence of lipophilicity on the diffusion of cephalosporins into the cerebrospinal fluid

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