Bacterial Contamination of Blood Components

Author:

Brecher Mark E.1,Hay Shauna N.1

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina

Abstract

SUMMARY Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference70 articles.

1. American Association of Blood Banks. 2003. Comprehensive report on blood collection and transfusion in the United States in 2001. National Blood Data Resource Center Bethesda Md.

2. American Association of Blood Banks. Bulletin. Guidance on implementation of new bacteria reduction and detection standard. http://www.aabb.org/members_only/archives/association_bulletins/ab03-10.htm .

3. Anderson, K. C., M. A. Lew, B. C. Gorgone, J. Martel, C. B. Leamy, and B. Sullivan. 1986. Transfusion-related sepsis after prolonged platelet storage. Am. J. Med.81:405-411.

4. Brecher, M. E. 2002. Bacterial contamination of blood products, p. 789. In T. L. Simon (ed.), Rossi's principles of transfusion medicine, 3rd ed. Lippincott, Williams and Wilkins, Baltimore, Md.

5. Brecher, M. E., G. Boothe, and A. Kerr. 1993. The use of a chemiluminescence-linked universal bacterial ribosomal RNA gene probe and blood gas analysis for the rapid detection of bacterial contamination in white cell reduced and nonreduced platelets. Transfusion33:450-457.

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