Affiliation:
1. Virogenetics Corporation, Troy, New York 12180.
Abstract
Two ALVAC (canarypox virus)-based recombinant viruses expressing the feline leukemia virus (FeLV) subgroup A env and gag genes were assessed for their protective efficacy in cats. Both recombinant viruses contained the entire gag gene. ALVAC-FL also expressed the entire envelope glycoprotein, while ALVAC-FL(dl IS) expressed an env-specific gene product deleted of the putative immunosuppressive region. Although only 50% of the cats vaccinated with ALVAC-FL(dl IS) were protected against persistent viremia after oronasal exposure to a homologous FeLV isolate, all cats administered ALVAC-FL resisted the challenge exposure. Significantly, protection was afforded in the absence of detectable FeLV-neutralizing antibodies. These results represent the first effective vaccination of cats against FeLV with a poxvirus-based recombinant vector and have implications that are relevant not only to FeLV vaccine development but also to developing vaccines against other retroviruses, including human immunodeficiency virus.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference35 articles.
1. Potential use of non-replicating vectors as recombinant vaccines;Baxby D.;Vaccine,1992
2. la.Brockmeier S. L. K. M. Lager J. Tartaglia M. Riviere E. Paoletti and W. L. Mengeling. Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses. Vet. Microbiol. in press.
3. Immunisation with canarypox virus expressing rabies glycoprotein;Cadoz M.;Lancet,1992
4. Inhibition of Iymphocyte proliferation by synthetic peptide homologous to retroviral envelope proteins;Cianciolo G. J.;Science,1985
5. Efficacy and safety field trials of a recombinant DNA vaccine against feline leukemia virus infection;Clark N.;J. Am. Vet. Med. Assoc.,1991
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