A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization-Reference-Cited by-同舟云学术

A New Actinomycin Complex Produced by a Micromonospora Species: Fermentation, Isolation, and Characterization

Published:1976-03 Issue:3 Volume:9 Page:465-469
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wagman G. H¹,Marquez J. A.¹,Watkins P. D.¹,Gentile F.¹,Murawski A.¹,Patel M.¹,Weinstein M. J.¹

Affiliation:

1. Microbiological Sciences, Schering Corporation, Bloomfield, New Jersey 07003

Abstract

A species of Micromonospora, Micromonospora floridensis NRRL 8020, has been found to produce an actinomycin complex consisting of at least 25 active components. After solvent extraction of the complex, separation of the individual components was carried out by preparative thin-layer chromatography. Hydrolysis and subsequent electrophoretic and chromatographic identification of the amino acid content of each of the isolated components have shown differences from known actinomycins, and the probability exists that these contain a number of amino or imino acids not previously found in other members of this group of antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.9.3.465

Reference10 articles.

1. Darstellung und Charakterisierung reiner Actinomycine;Brockmann H.;XII. Chem. Ber.,1954

2. Actinomycin. I. Amino acid content;Daigliesh C. E.;J. Chem. Soc., p.,1950

3. An actinomycin from a species of the genus Micromonospora;Fisher W. P.;Antibiot. Chemother.,1951

4. Actinomycin. IV. Classification of the actinomycins by paper chromatography;Gregory F. J.;Antibiot. Chemother.,1955

5. Variatons on a theme. The actinomycins;Katz E.;Appl. Microbiol.,1961

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