Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX—a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine-Reference-Cited by-同舟云学术

Enhanced Cross-Reactive and Polyfunctional Effector-Memory T Cell Responses by ICVAX—a Human PD1-Based Bivalent HIV-1 Gag-p41 Mosaic DNA Vaccine

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chen Samantha M. Y.¹,Wong Yik Chun¹,Yim Lok Yan¹,Zhang Haoji²,Wang Hui³,Lui Grace Chung Yan⁴,Li Xin¹²,Tang Xian³,Cheng Lin³,Du Yanhua¹,Peng Qiaoli¹³,Wang Jinlin¹,Kwok Hau-yee¹,Huang Haode¹,Lau Thomas Tsz-Kan¹,Chan Denise Pui Chung⁵,Wong Bonnie Chun Kwan⁴,Liu Li¹^ORCID,Chakrabarti Lisa A.⁶⁷,Lee Shui Shan⁵,Chen Zhiwei¹³^ORCID

Affiliation:

1. AIDS Institute, Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People’s Republic of China

2. Department of Veterinary Medicine, Foshan University, Foshan, People’s Republic of China

3. HKU-AIDS Institute Shenzhen Research Laboratory and AIDS Clinical Research Laboratory, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of China

4. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

5. Stanley Ho Centre for Emerging Infectious Diseases, Postgraduate Education Centre, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

6. Control of Chronic Viral Infection Group, Virus and Immunity Unit, Institut Pasteur, Paris, France

7. Centre National de la Recherche Scientifique, UMR 3569, Paris, France

Abstract

This study presents that ICVAX, a PD1-based DNA vaccine against HIV-1, could induce broad and polyfunctional T cell responses against different HIV-1 subtypes. ICVAX encodes a recombinant antigen consisting of the human soluble PD1 domain fused with two mosaic Gag-p41 antigens.

Funder

Mega-Projects of National Science Research for the 13th Five-Year Plan in China

FHB | Health and Medical Research Fund

HKU | University of Hong Kong

HKU | Li Ka Shing Faculty of Medicine, University of Hong Kong

University-Industry Collaboration Programme, Innovation and Technology Commission, the Government of Hong Kong Special Administration Region of the People's Republic of China

Theme-based Research Scheme, Hong Kong Research Grant Council

French National Research Agency (Agency Nationale de la Recherche)/RGC Joint Research Scheme, Hong Kong Research Grant Council

General Research Fund, Hong Kong Research Grant Council

Collaborative Research Fund, Hong Kong Research Grant Council

Shenzhen Science and Technology Innovation Commission | Sanming Project of Medicine in Shenzhen

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.02161-21

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