Conditional Dependence of Fusion from Within and Other Cell Membrane Alterations by Newcastle Disease Virus

Author:

Gallaher William R.1,Bratt Michael A.1

Affiliation:

1. Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Fusion from within (FFWI) by Newcastle disease virus occurs optimally in medium maintained at pH 8.2, whereas fusion from without is relatively insensitive to the pH of the medium in the range of 7.0 to 8.3. The pH-sensitive events in FFWI take place in the synthesis of the hypothetical fusion factor rather than in the response to it. pH pulse and pH shift experiments have localized the pH-sensitive events between 4 and 6.5 h postinfection (a period of synthesis of proteins required for FFWI), but before the fusion process. The pH sensitivity is not due to a pH-sensitive interference phenomenon. Virus production and the appearance of hemadsorbing cell surfaces are also pH sensitive, but for these functions the pH optima depend upon the virus strains tested. The independence of FFWI, hemadsorption, and virus production is discussed. Also discussed are the possible roles of virus-specific proteins in the fusion process.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference22 articles.

1. Fusion of erythrocytes by Sendai virus studied by immunofreeze-etching;Bachi T.;J. Virol.,1973

2. Bankowski R. A. 1964. Cytopathogenicity of Newcastle disease virus p. 231-246. In R. P. Hanson (ed.) Newcastle disease virus: an evolving pathogen University of Wisconsin Press. Madison.

3. Preliminary analysis of the requirements for fusion from within and fusion from without by Newcastle disease virus;Bratt M. A.;Proc. Nat. Acad. Sci. U.S.A.,1969

4. Comparison of fusion from within and fusion from without by Newcastle disease virus;Bratt M. A.;Vitro,1970

5. Bratt M. A. and W. R. Gallaher. 1972. Biological parameters of fusion from without and fusion from within p. 383-406. In C. F. Fox (ed.) Membrane research. Academic Press Inc. New York.

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