Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C-Reference-Cited by-同舟云学术

Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C

Published:2022-10-26 Issue:5 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Tang Jianli¹,Abdullah Sahibzada Waheed¹,Li Pinghua¹,Wu Jin'en¹,Pei Chenchen¹,Mu Suyu¹,Wang Yunlu²,Sun Shiqi¹,Guo Huichen¹³

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

2. College of Animal Science, University of Tibet Agricultural and Animal Husbandry, Linzhi, Tibet, China

3. College of Animal Science, Yangtze University, Jingzhou, Hubei, China

Abstract

FMDV is the leading cause of the foot-and-mouth disease (FMD), affecting cloven-hoofed animals with high morbidity and mortality. We determined that HSP60 is required for efficient viral RNA replication and mRNA translation during FMDV infection.

Funder

The National Key Research and Development Program

National Natural Science Foundation of China

Science and Technology Major Project of Gansu Province

Science and Technology Talents and Platform Program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01434-22

Reference62 articles.