Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes-Reference-Cited by-同舟云学术

Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Neumann Niels¹²^ORCID,Friz Simon¹²,Forchhammer Karl¹²^ORCID

Affiliation:

1. Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

2. Cluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany

Abstract

Glc-1,6-BP is known as an essential activator of phosphoglucomutase (PGM) and other members of the αPHM superfamily, making it a central regulator in glycogen metabolism, glycolysis, amino sugar formation as well as bacterial cell wall and capsule formation. Despite this essential role in carbon metabolism, its origin in prokaryotes has so far remained elusive.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01469-22

Reference36 articles.

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2. Biology, Mechanism, and Structure of Enzymes in the α- d -Phosphohexomutase Superfamily

3. Molecular Identification of Mammalian Phosphopentomutase and Glucose-1,6-bisphosphate Synthase, Two Members of the α-D-Phosphohexomutase Family