Author:
Muszanska Agnieszka K.,Nejadnik M. Reza,Chen Yun,van den Heuvel Edwin R.,Busscher Henk J.,van der Mei Henny C.,Norde Willem
Abstract
ABSTRACTBiofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains ofStaphylococcus aureus,Staphylococcus epidermidis, andPseudomonas aeruginosaadhered more weakly to brush-coated silicone rubber (−0.05 ± 0.03 to −0.51 ± 0.62 nN) than to uncoated silicone rubber (−1.05 ± 0.46 to −5.1 ± 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
47 articles.
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