Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wu Xuemei¹²^ORCID,Venkataramanan Raman¹³⁴,Rivosecchi Ryan M.⁵,Tang Chenxiao¹,Marini Rachel V.⁵,Shields Ryan K.⁶,Clancy Cornelius J.⁶⁷,Nguyen M. Hong⁶

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

3. Department of Surgery, School of Medicine, Thomas Starzl Transplantation Institute, Pittsburgh, Pennsylvania, USA

4. Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Pharmacy & Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

6. Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

7. VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA

Abstract

Isavuconazole (ISA) is a triazole antifungal with activity against yeasts and molds. We established a population pharmacokinetic (pop PK) model of intravenous (i.v.) ISA to identify covariates that affect pharmacokinetics, using plasma samples from solid-organ transplant (SOT) recipients receiving peritransplant prophylaxis. Samples ( n = 471) from 79 SOT recipients were utilized for pop PK analysis using nonlinear mixed-effect modeling NONMEM software.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01728-19

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