Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis-Reference-Cited by-同舟云学术

Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lasko Maxwell J.¹,Conelius Allison M.²,Serrano Oscar K.³⁴,Nicolau David P.¹⁵^ORCID,Kuti Joseph L.¹^ORCID

Affiliation:

1. Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA

2. Hartford Healthcare Heart and Vascular Institute, Hartford Hospital, Hartford, Connecticut, USA

3. Transplant and Comprehensive Liver Center, Hartford Hospital, Hartford, Connecticut, USA

4. University of Connecticut School of Medicine, Department of Surgery, Farmington, Connecticut, USA

5. Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut, USA

Abstract

Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an ex vivo IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation.

Funder

Hartford Hospital Department of Medicine

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01725-20

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