Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake-Reference-Cited by-同舟云学术

Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake

Published:2018-01 Issue:1 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mulder T.¹^ORCID,Kluytmans-van den Bergh M. F. Q.¹²³,Crolla R. M. P. H.⁴,Ermens A. A. M.⁵,Romme J.³,van‘t Veer N. E.⁶,Kluytmans J. A. J. W.¹³

Affiliation:

1. Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands

2. Amphia Academy Infectious Disease Foundation, Amphia Hospital, Breda, The Netherlands

3. Laboratory for Microbiology and Infection Control, Amphia Hospital, Breda, The Netherlands

4. Department of Surgery, Amphia Hospital, Breda, The Netherlands

5. Laboratory for Clinical Chemistry and Hematology, Amphia Hospital, Breda, The Netherlands

6. Department of Clinical Pharmacy, Amphia Hospital, Breda, The Netherlands

Abstract

ABSTRACT Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01723-17

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