Coexistence ofmcr-1andblaNDM-1in Escherichia coli from Venezuela-Reference-Cited by-同舟云学术

Coexistence ofmcr-1andblaNDM-1in Escherichia coli from Venezuela

Published:2016-07-18 Issue:10 Volume:60 Page:6356-6358
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Delgado-Blas Jose F.,Ovejero Cristina M.,Abadia-Patiño Lorena,Gonzalez-Zorn Bruno

Abstract

ABSTRACTWe studied the presence of the mobile colistin resistance genemcr-1in human, animal, and environmentalEnterobacteriaceaesamples from Cumana, Venezuela, that were collected in 2015. Themcr-1gene was detected in 2/93Escherichia coliisolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identifiedmcr-1on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.

Funder

European Commission (EC)

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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