Integron-Borne Transmission of VEB-1 Extended-Spectrum β-Lactamase in Pseudomonas aeruginosa in a Tertiary Care Hospital in India

Author:

Maurya Anand Prakash,Talukdar Anupam Das,Chanda Debadatta Dhar,Chakravarty Atanu,Bhattacharjee Amitabha

Abstract

ABSTRACTA total 14 clinical isolates ofPseudomonas aeruginosathat produced VEB-1 and were susceptible only to polymyxin B were recovered from hospitalized patients. VEB-1 was located within variable regions of the class 1 integron, flanked by resistant genes, and was horizontally transferable as well as carried within the IncP-type plasmid. We conclude that the IncP-type plasmid is responsible for the horizontal transmission of VEB-1-mediated expanded-spectrum cephalosporin resistance in this medical center.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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