Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity-Reference-Cited by-同舟云学术

Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Law Yee-Song¹²,Wang Sainan³,Tan Yaw Bia¹²,Shih Orion⁴,Utt Age³,Goh Wei Yang²⁵,Lian Bing-Jun⁴⁶,Chen Ming Wei²⁵,Jeng U-Ser⁴⁶,Merits Andres³^ORCID,Luo Dahai¹²⁵^ORCID

Affiliation:

1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

2. NTU Institute of Structural Biology, Nanyang Technological University, Singapore

3. Institute of Technology, University of Tartu, Tartu, Estonia

4. National Synchrotron Radiation Research Center, Hsinchu, Taiwan ROC

5. School of Biological Sciences, Nanyang Technological University, Singapore

6. Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan ROC

Abstract

CHIKV nsP2 plays multiple roles in viral RNA replication and virus-host interactions. The helicase and protease regions of nsP2 are connected through a short linker.

Funder

Ministry of Education - Singapore

EC | European Regional Development Fund

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01470-20

Reference40 articles.

1. Chikungunya: a re-emerging virus