Affiliation:
1. National Institute for Medical Research, London, N. W. 7, England
Abstract
Pools of rat antiserum to
Plasmodium berghei
had different levels of protective activity as assessed by a passive transfer test. Preincubation of parasite inocula with an effective pool before injection did not significantly enhance protective activity. Removal of the antiserum from preincubated parasite inocula abolished the bulk of protective activity. Similarly, antiserum effective in intact animals was largely ineffective in splenectomized recipients. These experiments suggest a minimal role for antibody acting directly on
P. berghei
-parasitized cells and reemphasize a significant role for the spleen in immunity to this plasmodium.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
24 articles.
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