Phagocytosis and intracellular killing of Staphylococcus aureus by normal mouse peritoneal macrophages

Author:

Baughn R,Bonventre P F

Abstract

Although Staphylococcus aureus is incapable of intracellular multiplication in cultured mouse peritoneal macrophages, it is killed at a much slower rate than the avirulent Staphylococcus epidermidis. In addition to the presence of capsular material which inhibits phagocytosis of specific strains of S. aureus, the data show that a number of cellular and environmental factors affect the functional capacities of mononuclear phagocytic cells. The data obtained by varying the initial level of infection indicate that the number of ingested bacteria may subsequently alter the kinetics of intracellular killing. In vitro maturation of macrophages in culture was also found to exert a pronounced effect on the kinetics of bacterial death.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference25 articles.

1. Cell-mediated immune phenomena induced by Iymphokines from splenic Iymphocytes of mice with chronic staphylococcal infection;Baughn R. E.;Infect. Immun.,1975

2. Long term cultivation of mouse peritoneal macrophages;Chang Y. T.;J. Natl. Cancer Inst.,1964

3. Suppressive activity of streptomycin on the growth of Mycobacterium lepraemurium in macrophage cultures;Chang Y. T.;Appl. Microbiol.,1969

4. The differentiation of mononuclear phagocytes. II. The influence of serum on granule formation, hydrolase production and phagocytosis;Cohn Z. A.;J. Exp. Med.,1965

5. The differentiation of mononuclear phagocytes. V. The formation of macrophage Iysosomes;Cohn Z. A.;J. Exp. Med.,1966

Cited by 44 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3