The Genome of Non-O1 Vibrio cholerae NRT36S Demonstrates the Presence of Pathogenic Mechanisms That Are Distinct from Those of O1 Vibrio cholerae

Author:

Chen Yuansha1,Johnson Judith A.12,Pusch Gordon D.3,Morris J. Glenn1,Stine O. Colin1

Affiliation:

1. University of Maryland, Baltimore, Maryland 21201

2. Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201

3. National Microbial Pathogen Data Resource, Chicago, Illinois

Abstract

ABSTRACT Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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