The HtrA stress response protease contributes to resistance of Brucella abortus to killing by murine phagocytes

Author:

Elzer P H1,Phillips R W1,Robertson G T1,Roop R M1

Affiliation:

1. Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130-3932, USA.

Abstract

Compared with virulent Brucella abortus 2308, the isogenic htrA mutant PHE1 shows decreased resistance to killing by cultured murine neutrophils and macrophages and significant attenuation during the early stages of infection in the BALB/c mouse model. These findings further define the contributions of the htrA gene product to the pathogenesis of B. abortus infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference30 articles.

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3. Salmonella typhimurium loci involved in survival within macrophages;Bäumler A. J.;Infect. Immun.,1994

4. Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA;Boucher J. C.;J. Bacteriol.,1996

5. Cloning, expression, and occurrence of the Brucella Cu-Zn superoxide dismutase;Bricker B. J.;Infect. Immun.,1990

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