Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon-Reference-Cited by-同舟云学术

Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon

Published:1993-08 Issue:8 Volume:61 Page:3565-3569
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Manna P P¹,Bharadwaj D¹,Bhattacharya S¹,Chakrabarti G¹,Basu D¹,Mallik K K¹,Bandyopadhyay S¹

Affiliation:

1. Indian Institute of Chemical Biology, Calcutta.

Abstract

Indian kala-azar patients have normal numbers of peripheral blood NK cells but impaired functional activity due to decreased binding and lysis of target cells. This impairment of NK activity could not be corrected by exogenous recombinant human alpha or gamma interferon. However, recombinant human interleukin 2 was able to restore this activity by augmenting conjugate formation and lysis of target cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.61.8.3565-3569.1993

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