The dermatophytes

Author:

Weitzman I1,Summerbell R C1

Affiliation:

1. Clinical Microbiology Service, Columbia Presbyterian Medical Center, New York, New York 10032-3784, USA.

Abstract

The etiologic agents of the dermatophytoses (ringworm) are classified in three anamorphic (asexual or imperfect) genera, Epidermophyton, Microsporum, and Trichophyton. Species capable of reproducing sexually belong in the teleomorphic genus, Arthroderma, of the Ascomycota. On the basis of primary habitat association, they may be grouped as geophilic (soil associated), zoophilic, and anthropophilic. Adaptation to growth on humans by most geophilic species resulted in diminished loss of sporulation, sexuality, and other soil-associated characteristics. The dermatophytes have the ability to invade keratinized tissue (skin, hair, and nails) but are usually restricted to the nonliving cornified layer of the epidermis because of their inability to penetrate viable tissue of an immunocompetent host. However, invasion does elicit a host response ranging from mild to severe. Acid proteinases, elastase, keratinases, and other proteinases reportedly act as virulence factors. The development of cell-mediated immunity correlated with delayed hypersensitivity and an inflammatory response is associated with clinical cure, whereas the lack of or a defective cell-mediated immunity predisposes the host to chronic or recurrent dermatophyte infection. Chronic dermatophytosis is mostly caused by Trichophyton rubrum, and there is some evidence that mannan produced by this fungus suppresses or diminishes the inflammatory response. Since dermatophytes cause a communicable disease, modes of transmission and control are discussed as well as a survey of recent trends in therapy. Collection of specimens, culture media, and tests for identification are also presented. Genetic studies have led to an understanding of incompatibility mechanisms, pleomorphism and variation, resistance to griseofulvin, and virulence. Molecular biology has contributed to our knowledge of the taxonomy and phylogenetic relationships of dermatophytes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

Reference284 articles.

1. Present day concepts in the dermatophytes;Ajello L.;Mycopathol. Mycol. Appl.,1962

2. A taxonomic review of the dermatophytes and related species;Ajello L.;Sabouraudia,1968

3. Natural history of the dermatophytes and related fungi;Ajello L.;Mycopathol. Mycol. Appl.,1974

4. Ajello L. 1977. Milestones in the history of medical mycology: the dermatophytes p. 3-11. In K. Iwata (ed.) Recent advances in medical and veterinary mycology. University of Tokyo Press Tokyo.

5. Ajello L. 1977. Taxonomy of the dermatophytes: a review of their imperfect and perfect states p. 289-297. In K. Iwata (ed.) Recent advances in medical and veterinary mycology. University of Tokyo Press Tokyo.

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