Emergence of Metallo-β-Lactamase NDM-1-Producing Multidrug-Resistant Escherichia coli in Australia-Reference-Cited by-同舟云学术

Emergence of Metallo-β-Lactamase NDM-1-Producing Multidrug-Resistant Escherichia coli in Australia

Published:2010-11 Issue:11 Volume:54 Page:4914-4916
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Poirel Laurent¹,Lagrutta Emilie¹,Taylor Peter²,Pham Jeanette²,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, INSERM U914 “Emerging Resistance to Antibiotics,” Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France

2. Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia

Abstract

ABSTRACT A multidrug-resistant Escherichia coli isolate recovered in Australia produced a carbapenem-hydrolyzing β-lactamase. Molecular investigations revealed the first identification of the bla NDM-1 metallo-β-lactamase gene in that country. In addition, this E. coli isolate expressed the extended-spectrum β-lactamase CTX-M-15, together with two 16S rRNA methylases, namely, ArmA and RmtB, conferring a high level of resistance to aminoglycosides.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00878-10

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