Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae-Reference-Cited by-同舟云学术

Synergistic Activity of Colistin-Containing Combinations against Colistin-Resistant Enterobacteriaceae

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Brennan-Krohn Thea¹²³,Pironti Alejandro⁴,Kirby James E.¹³

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

Abstract

Resistance to colistin, a polypeptide drug used as an agent of last resort for the treatment of infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae (CRE), severely limits treatment options and may even transform an XDR organism into one that is pan-resistant. We investigated the synergistic activity of colistin in combination with 19 antibiotics against a collection of 20 colistin-resistant Enterobacteriaceae isolates, 15 of which were also CRE.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00873-18

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