Clinical Response and Tolerability to and Safety of Saquinavir with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Mothers and Their Infants-Reference-Cited by-同舟云学术

Clinical Response and Tolerability to and Safety of Saquinavir with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Mothers and Their Infants

Published:2007-06 Issue:6 Volume:51 Page:2208-2210
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zorrilla Carmen D.¹,Van Dyke Russell²,Bardeguez Arlene³,Acosta Edward P.⁴,Smith Betsy⁵,Hughes Michael D.⁶,Huang Sharon⁶,Watts D. Heather⁷,Heckman Barbara⁸,Jiménez Eleanor⁹,McSherry George³,Mofenson Lynne⁸

Affiliation:

1. University of Puerto Rico School of Medicine, San Juan, Puerto Rico

2. Tulane University Medical School, New Orleans, Louisiana

3. New Jersey Medical School, Newark, New Jersey

4. University of Alabama at Birmingham, Birmingham, Alabama

5. Division of AIDS, NIAID, Bethesda, Maryland

6. Harvard School of Public Health, Boston, Massachusetts

7. Pediatric, Adolescent, and Maternal AIDS Branch, NICHD, Bethesda, Maryland

8. Frontier Science and Technology Research Foundation, Amherst, New York

9. San Juan City Hospital, San Juan, Puerto Rico

Abstract

ABSTRACT Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00871-06

Reference9 articles.

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