Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation

Author:

Pollard Morris1,Sharon Nehama1

Affiliation:

1. Lobund Laboratory, University of Notre Dame, Notre Dame, Indiana 46556

Abstract

Lymph nodes, spleens, and Peyer's patches of germ-free mice are relatively inactive. The tissues are small and contain rare, small, indistinct, germinal zones. When exposed to antigenic stimuli ( Salmonella paratyphi A and lymphocytic choriomeningitis virus), the tissues become larger and germinal zones appear coincident with antibodies in the blood. The Peyer's patches were activated if antigen was absorbed from the intestinal lumen into the circulation but not if the antigen was administered parenterally. There was no demonstrable immunological response by the germ-free mouse to Streptococcus faecalis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference12 articles.

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2. Development of IgM memory in rats after antigenic stimulation of Peyer's patches;Cooper G. N.;J. Reticuloendothelial Soc.,1969

3. Bacterienfreie mierschweinchen. Aulzucht, Lebensfahigkeit und Wachstum nebst Untersuchungen uber das Iymphatische Gewebe;Glimstedt G.;Acta Pathol. Microbiol. Scand. (Suppl.),1936

4. Wide distribution of leukemia virus in strains of laboratory mice;Kajima M.;Nature (London),1968

5. Immunological function of the thymus;Miller J. F. A. P.;Lancet,1961

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