Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway-Reference-Cited by-同舟云学术

Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Berry Noémie¹²^ORCID,Suspène Rodolphe¹,Caval Vincent¹,Khalfi Pierre¹²,Beauclair Guillaume³^ORCID,Rigaud Stéphane⁴,Blanc Hervé⁵,Vignuzzi Marco⁵^ORCID,Wain-Hobson Simon¹,Vartanian Jean-Pierre¹^ORCID

Affiliation:

1. Molecular Retrovirology Unit, Institut Pasteur, Paris, France

2. Sorbonne Université, Complexité du Vivant, Paris, France

3. Viral Genomics and Vaccination, Institut Pasteur, Paris, France

4. Hub d’Analyse d’Images, Institut Pasteur, Paris, France

5. Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, Paris, France

Abstract

Herpes simplex virus 1 (HSV-1) impairs the mitochondrial network through the viral protein UL12.5. This leads to the fusion of mitochondria and simultaneous release of mitochondrial DNA (mtDNA) in a mouse model.

Funder

Ministere de la recherche

Ligue Contre le Cancer

Institut Pasteur

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02557-21

Reference63 articles.

1. Mitochondria are the powerhouses of immunity