Targetome Analysis of Malaria Sporozoite Transcription Factor AP2-Sp Reveals Its Role as a Master Regulator-Reference-Cited by-同舟云学术

Targetome Analysis of Malaria Sporozoite Transcription Factor AP2-Sp Reveals Its Role as a Master Regulator

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Yuda Masao¹^ORCID,Kaneko Izumi¹,Murata Yuho¹,Iwanaga Shiroh²,Nishi Tsubasa¹

Affiliation:

1. Department of Medical Zoology, Mie University School of Medicine, Mie, Tsu, Japan

2. Department of Molecular Protozoology, Research Center for Infectious Disease Control, Suita, Osaka, Japan

Abstract

The sporozoite stage plays a central role in malaria transmission from a mosquito to vertebrate host and is an important target for antimalarial strategies. AP2-Sp is a candidate master transcription factor for the sporozoite stage.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02516-22

Reference35 articles.

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2. Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains

3. A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle

4. Identification of a transcription factor in the mosquito-invasive stage of malaria parasites

5. Transcription factor AP2-Sp and its target genes in malarial sporozoites

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