Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector-Reference-Cited by-同舟云学术

Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kumar Sudhir¹^ORCID,Haile Meseret T.¹,Hoopmann Michael R.²^ORCID,Tran Linh T.³^ORCID,Michaels Samantha A.³^ORCID,Morrone Seamus R.²^ORCID,Ojo Kayode K.³^ORCID,Reynolds Laura M.¹,Kusebauch Ulrike²^ORCID,Vaughan Ashley M.¹⁴^ORCID,Moritz Robert L.²^ORCID,Kappe Stefan H. I.¹⁵⁴^ORCID,Swearingen Kristian E.²^ORCID

Affiliation:

1. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

2. Institute for Systems Biology, Seattle, Washington, USA

3. Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA

4. Department of Pediatrics, University of Washington, Seattle, Washington, USA

5. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

Transmission of the malaria parasite to the mosquito vector is critical for the completion of the sexual stage of the parasite life cycle and is dependent on the release of male gametes from the gametocyte body inside the mosquito midgut. In the present study, we demonstrate that PfCDPK4 is critical for male gametogenesis and is involved in phosphorylation of proteins essential for male gamete emergence.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02575-21

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1. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum

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