VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains-Reference-Cited by-同舟云学术

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

So Jaime¹^ORCID,Sudlow Sarah¹,Sayeed Abeer¹,Grudda Tanner¹,Deborggraeve Stijn²,Ngoyi Dieudonné Mumba³,Desamber Didier Kashiama⁴,Wickstead Bill⁵^ORCID,Lejon Veerle⁶^ORCID,Mugnier Monica R.¹^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

3. Department of Parasitology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo

4. Programme Nationale de Lutte contre la Trypanosomiase Humaine Africaine (PNLTHA), Ministry of Health, Kinshasa, Democratic Republic of the Congo

5. School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom

6. UMR-177 Intertryp, Institut de Recherche pour le Développement, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, University of Montpellier, Montpellier, France

Abstract

Human African trypanosomiasis is a neglected tropical disease primarily caused by the extracellular parasite Trypanosoma brucei gambiense . To avoid elimination by the host, these parasites repeatedly replace their variant surface glycoprotein (VSG) coat.

Funder

HHS | National Institutes of Health

Research Foundation Flanders

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02553-22

Reference80 articles.

1. Trypanosoma brucei