CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs-Reference-Cited by-同舟云学术

CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Xiao Han¹,Wyler Emanuel²,Milek Miha²,Grewe Bastian³,Kirchner Philipp⁴,Ekici Arif⁴,Silva Ana Beatriz Oliveira Villela¹,Jungnickl Doris¹,Full Florian¹,Thomas Marco¹^ORCID,Landthaler Markus²⁵,Ensser Armin¹^ORCID,Überla Klaus¹^ORCID

Affiliation:

1. Institute of Clinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

2. Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

3. Department of Molecular and Medical Virology, Ruhr-University, Bochum, Germany

4. Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany

5. IRI Life Sciences, Institute für Biologie, Humboldt Universität zu Berlin, Berlin, Germany

Abstract

To regulate its complex splicing pattern, HIV-1 uses the adaptor protein Rev to shuttle unspliced or partially spliced mRNA from the nucleus to the cytoplasm. In the absence of Rev, these RNAs are retained in the nucleus, but it is unclear why.

Funder

China Scholarship Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02525-20

Reference98 articles.

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