Effect of Azithromycin plus Rifampin versus That of Azithromycin Alone on the Eradication of Chlamydia pneumoniae from Lung Tissue in Experimental Pneumonitis

Author:

Wolf Katerina1,Malinverni Raffaele12

Affiliation:

1. Department of Clinical Research1 and

2. Medical Policlinic,2 Inselspital, University of Bern, Bern, Switzerland

Abstract

ABSTRACT Azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against Chlamydia pneumoniae AR-39. The combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of C. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference19 articles.

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2. Detection of Chlamydia pneumoniae by polymerase chain reaction

3. Treatment of nongonococcal urethritis with rifampicin as a means of defining the role of Ureaplasma urealyticum.;Coufalik E. D.;Br. J. Vener. Dis.,1979

4. Chronic infections and coronary heart disease: is there a link?;Danesk J.;Lancet,1997

5. Chemical and biological properties of rifampicin.;Furesz S.;Antibiot. Chemother. (Basel),1970

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