Effect of HSR-903, a New Fluoroquinolone, on the Concentration of Theophylline in Serum-Reference-Cited by-同舟云学术

Effect of HSR-903, a New Fluoroquinolone, on the Concentration of Theophylline in Serum

Published:1999-06 Issue:6 Volume:43 Page:1494-1496
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Niki Yoshihito¹,Watanabe Shinsuke¹,Tamada Sadao¹,Yoshida Koichiro¹,Miyashita Naoyuki¹,Nakajima Masamitu¹,Matsushima Toshiharu¹,Sekino Hisayuki²,Matsuoka Osamu²

Affiliation:

1. Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192,1 and

2. Sekino Hospital, 3-28-3, Ikebukuro, Toshima-ku, Tokyo 171-0014,2 Japan

Abstract

ABSTRACT The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.6.1494

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