Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam, a Novel Aminopenicillin–β-Lactamase Inhibitor Combination, against Escherichia coli-Reference-Cited by-同舟云学术

Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam, a Novel Aminopenicillin–β-Lactamase Inhibitor Combination, against Escherichia coli

Published:1999-06 Issue:6 Volume:43 Page:1503-1504
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bantar Carlos¹,Nicola Federico¹,Arenoso Hector J.²,Galas Marcelo³,Soria Liliana⁴,Dana Diego⁵,Rossi Alicia³,Bianchini Hebe¹,Jasovich Abel⁴

Affiliation:

1. Centro de Educación Médica e Investigaciones Clı́nicas,1

2. Laboratorios Bagó S.A.,2

3. Instituto Nacional de Microbiologı́a “Carlos Malbrán”,3

4. Hospital Privado Antártida,4 and

5. Centro de Farmacologı́a Clı́nica Aplicada,5 Buenos Aires, Argentina

Abstract

ABSTRACT We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a novel drug combination, and its pharmacodynamics against Escherichia coli in 12 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericidal and urine inhibitory activities in most volunteers were observed against E. coli strains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 strains) and high (≥16-mg/liter) (47 strains), respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.6.1503

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