Author:
Tanaka A,Nagao S,Nagao R,Kotani S,Shiba T,Kusumoto S
Abstract
Muramyl dipeptide (MDP), a part of bacterial cell wall peptidoglycans, was active as adjuvant and stimulated the reticuloendothelial system (RES) of mice to increase its phagocytic function. A series of analogs of MDP was tested for their adjuvant activity and RES-stimulating activity. Sex differences were observed in the adjuvant activity and RES-stimulating capacity of some MDP analogs. A stereochemically highly specific structure required for MDP to exert adjuvant activity was also required for its RES-stimulating activity. Based on this close correlation among the structure, adjuvant activity, and RES-stimulating capacity of MDP, we infer that macrophages may play an important role in the expression of adjuvant activity of MDP.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference35 articles.
1. Correlation of structure and adjuvant activity of N-acetylmuramyl-Lalanyl-D-isoglutamine (MDP), its derivatives and analogues;Adam A.;Biochem. Biophys. Res. Commun.,1976
2. Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyldipeptide and related compounds;Azuma I.;Infect. Immun.,1976
3. Effect of bacterial endotoxins on the reticuloendothelial system;Benacerraf B.;Fed. Proc.,1957
4. The effect of Salnonella typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice;Biozzi G.;Br. J. Exp. Pathol.,1955
5. Oestrogenes et fonction phagocytaire du SRE;Biozzi G.;C. R. Seances Soc. Biol. Fil.,1957
Cited by
81 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献