Author:
Nguyen Linh Thuy,Dunford Linda,Freitas Ines,Holder Paul,Nguyen Lan Anh,O'Gorman Joanne,Connell Jeff,Carr Michael,Hall William,De Gascun Cillian
Abstract
Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV)coreregion from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P< 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic.
Publisher
American Society for Microbiology
Cited by
17 articles.
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