Mechanisms of Macrolide Resistance in Clinical Pneumococcal Isolates in France

Author:

Fitoussi Frederic1,Doit Catherine1,Geslin Pierre2,Brahimi Naima1,Bingen Edouard1

Affiliation:

1. Service de Microbiologie, Hôpital Robert Debré, 75019 Paris,1 and

2. Centre National de Référence des Pneumocoques, Centre Hospitalier de Créteil, 94010 Créteil,2 France

Abstract

ABSTRACT The genetic basis of macrolide resistance was investigated in a collection of 48 genotypically unrelated clinical isolates of Streptococcus pneumoniae obtained between 1987 and 1997 in France. All strains were resistant to erythromycin, clindamycin, and streptogramin B, exhibiting a macrolide-lincosamide-streptogramin B resistance phenotype, and harbored the erm (B) gene. None of the strains carried the mef (A) or erm (A) subclass erm (TR) gene.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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