Factors Influencing Susceptibility of Nocardia Species to Trimethoprim-Sulfamethoxazole-Reference-Cited by-同舟云学术

Factors Influencing Susceptibility of Nocardia Species to Trimethoprim-Sulfamethoxazole

Published:1978-04 Issue:4 Volume:13 Page:624-627
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bennett John E.¹,Jennings Anne E.²

Affiliation:

1. Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland 20014

2. Department of Clinical Pathology, Clinical Center, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.13.4.624

Reference15 articles.

1. Nocardiosis;Adams A. R.;Med. J. Aust.,1971

2. Systemic nocardisis treated with trimethoprim and sulphamethoxazole;Baikie A. G.;Lancet,1970

3. Trimethoprim as a possible therapy for nocardiosis and melioidosis;Beaumont R. J.;Med. J. Aust.,1970

4. Sensitivity of Nocardia to trimethoprim and sulfonamides in vitro;Black W. A.;J. Clin. Pathol.,1970

5. Trimethoprim-sulfamethoxazole: in vitro microbiological aspects;Bushby S. R. M.;J. Infect. Dis.,1973

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