Affiliation:
1. Departments of Medicine and Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032
Abstract
The in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other β-lactam compounds. Cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 μg or less per ml, and staphylococci were inhibited by 1.6 μg or less per ml. Enterococci were relatively resistant. Cefuroxime inhibited β-lactamase-producing
Neisseria gonorrhoeae
and
Haemophilus influenzae
. Cefuroxime had excellent activity against members of the
Enterobacteriaceae;
83% of β-lactamase-producing
Escherichea coli
, 100% of
Salmonella
, 100% of
Klebsiella
, 90% of
Proteus mirabilis
, 95% of
Citrobacter
, 56% of
Enterobacter
, and 58% of
Shigella
were inhibited by 12.5 μg/ml. Cefuroxime had activity comparable to that of cefamandole and cefoxitin; it inhibited isolates of
E. coli
and
Klebsiella
resistant to cefamandole and inhibited
Enterobacter
and
Citrobacter
resistant to cefoxitin. Many isolates of
Serratia
, some indole-positive strains of
Proteus
, and
Bacteroides fragilis
were resistant to cefuroxime. Resistance of cefuroxime to hydrolysis by β-lactamases played a major role in its activity against both gram-positive and gram-negative organisms.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
89 articles.
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