Affiliation:
1. Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
Abstract
The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from chronically infected mothers are protected from congenital toxoplasmosis, rat infection could thus constitute a relevant model for immunological studies and vaccine design.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference29 articles.
1. L'embryotoxicite des medicaments. Notes experimentales;Bertrand M.;Cah. Med. Vet.,1972
2. Congenital transmission of toxoplasmosis through successive generations of mice;Beverley J. K. A.;Nature (London),1959
3. Congenital toxoplasmosis in twins. A series of 14 pairs of twins: absence of infection in one twin in two pairs;Couvreur J.;J. Pediatr.,1976
4. Experimental congenital toxoplasmosis. I. The vagina as a portal of entry of Toxoplasma in the mouse;Cowen D.;J. Exp. Med.,1950
5. Induction of a protective antibody-dependent response against toxoplasmosis by in vitro excreted-secreted antigens from tachyzoites of Toxoplasma gondii;Darcy F.;Parasite Immunol.,1988
Cited by
54 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献